MaterialsAtlas Synthesis Resource
Sonogashira coupling
Reaction families and named transformationsreaction family guidegraduate synthetic chemistchemical synthesisgraduate trainingOrganic Chemistry Portalreaction classnamed reactionmethod selectionSonogashiracoupling
Sonogashira coupling is a ChemistryAtlas synthesis guide card for reaction families and named transformations. It focuses on choosing conditions, substrates, scope, and failure modes for a transformation.
- Start with the linked source: Organic Chemistry Portal.
- Compare at least two literature precedents before using the chemistry on a valuable substrate.
- Record reagent equivalents, concentration, temperature, atmosphere, time, workup, purification, yield, and characterization.
- When this topic is useful in a synthesis plan.
- Which variables usually control success or failure.
- What evidence is needed before trusting the product assignment.
Characterization expectation: include at minimum 1H NMR, 13C NMR when applicable, LC-MS or HRMS, and purity evidence appropriate to the product class.
Safety expectation: complete a written hazard and quench plan before starting; confirm scale, gas/pressure risk, thermal risk, and emergency controls with a supervisor.
Recommended level: graduate synthetic chemist. Resource type: reaction family guide.
Citation: Organic Chemistry Portal named reactions and methods reference.